Properties of the delayed rectifier potassium current in porcine sino‐atrial node cells
نویسندگان
چکیده
منابع مشابه
A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells.
We have investigated the physiological role of the "rapidly activating" delayed rectifier K+ current (IKr) in pacemaker activity in isolated sinoatrial node (SAN) myocytes and the expression of mouse ether-a-go-go (mERG) genes in the adult mouse SAN. In isolated, voltage-clamped SAN cells, outward currents evoked by depolarizing steps (greater than -40 mV) were strongly inhibited by the class I...
متن کاملDelayed rectifier potassium current in undiseased human ventricular myocytes.
OBJECTIVE The purpose of the study was to investigate the properties of the delayed rectifier potassium current (IK) in myocytes isolated from undiseased human left ventricles. METHODS The whole-cell configuration of the patch-clamp technique was applied in 28 left ventricular myocytes from 13 hearts at 35 degrees C. RESULTS An E-4031 sensitive tail current identified the rapid component of...
متن کاملEffects of allocryptopine on outward potassium current and slow delayed rectifier potassium current in rabbit myocardium
OBJECTIVE Allocryptopine (ALL) is an effective alkaloid of Corydalis decumbens (Thunb.) Pers. Papaveraceae and has proved to be anti-arrhythmic. The purpose of our study is to investigate the effects of ALL on transmural repolarizing ionic ingredients of outward potassium current (I to) and slow delayed rectifier potassium current (I Ks). METHODS The monophasic action potential (MAP) techniqu...
متن کاملBlockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion.
Delayed-rectifier K+ currents (I(DR)) in pancreatic beta-cells are thought to contribute to action potential repolarization and thereby modulate insulin secretion. The voltage-gated K+ channel, K(V)2.1, is expressed in beta-cells, and the biophysical characteristics of heterologously expressed channels are similar to those of I(DR) in rodent beta-cells. A novel peptidyl inhibitor of K(V)2.1/K(V...
متن کاملExistence of a delayed rectifier K+ current in the membrane of human embryonic stem cel
Introduction: Human embryonic stem cells (hESCs) are pluripotent cells that can proliferate and differentiate to many cell types. Their electrophysiological properties have not yet been chracterzed. In this study, the passive properties (such as resting membrane potential, input resistance and capacitance) and the contribution of delayed rectifier K+ channel currents to the membrane conducta...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2000
ISSN: 0022-3751,1469-7793
DOI: 10.1111/j.1469-7793.2000.00051.x